The Gavis Lab

Gavis lab group photo 2024

Welcome to the Gavis Lab

Gene transcription is only the first step in ensuring that proteins are expressed in the right time and place. The localization, translation, and degradation of RNAs must be carefully coordinated to provide the spatial control of protein expression that allows cells to adopt unique fates in developing embryos and generate specialized subcellular regions such as neuronal dendrites.

RNAs are regulated by hundreds of different RNA-binding proteins encoded in the genome. Interactions between RNA-binding proteins and their target RNAs can create dynamic subcellular compartments known as granules, where many of the post-transcriptional regulatory steps take place. Our lab uses high-resolution microscopy, genetics, and biochemistry to investigate how RNA granules assemble and how they regulate cell fate and function. We also study mechanisms used by RNA-binding proteins to recognize and control translation of their target mRNAs.

Learn more about our Research

Recent Publications

Siddiqui N, Karaiskakis A, Goldman A, Eagle W V, Low T, Luo H, Smibert C, Gavis E, Lipshitz H. Smaug regulates germ plasm assembly and primordial germ cell number in Drosophila embryos. Science advances. 2024;10(15):eadg7894. PMCID: PMC11014450
Breznak S, Peng Y, Deng L, Kotb N, Flamholz Z, Rapisarda I, Martin E, LaBarge K, Fabris D, Gavis E, Rangan P. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Science advances. 2023;9(25):eade5492. PMCID: PMC10284551
Warden M, DeRose E, Tamayo J V, Mueller G, Gavis E, Hall T. The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos. Nucleic acids research. 2023;. PMID: 37427795
Eichler C, Li H, Grunberg M, Gavis E. Localization of oskar mRNA by agglomeration in ribonucleoprotein granules. PLoS genetics. 2023;19(8):e1010877. PMID: 37624861