@article{84091,
  keywords = {Animals, Drosophila, signal transduction, RNA, Messenger, Transcription Factors, Protein Biosynthesis, Phenotype, DNA-Binding Proteins, Female, Male, Gene Expression Regulation, Developmental, Body Patterning, Animals, Genetically Modified, Saccharomyces cerevisiae Proteins, Fungal Proteins, Drosophila Proteins, RNA-Binding Proteins, Genes, Insect, Insect Proteins, Neurosecretory Systems},
  author = {Ira Clark and Krista Dobi and Heather Duchow and Anna Vlasak and Elizabeth Gavis},
  title = {A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila.},
  abstract = {<p>Translational repression of maternal nanos (nos) mRNA by a cis-acting Translational Control Element (TCE) in the nos 3{\textquoteright}UTR is critical for anterior-posterior patterning of the Drosophila embryo. We show, through ectopic expression experiments, that the nos TCE is capable of repressing gene expression at later stages of development in neuronal cells that regulate the molting cycle. Our results predict additional targets of TCE-mediated repression within the nervous system. They also suggest that mechanisms that regulate maternal mRNAs, like TCE-mediated repression, may function more widely during development to spatially or temporally control gene expression.</p>
},
  year = {2002},
  journal = {Development},
  volume = {129},
  pages = {3325-34},
  month = {07/2002},
  issn = {0950-1991},
  language = {eng},
}