@article{84036,
  keywords = {Animals, Drosophila, Chromosomes, Mutation, RNA, Messenger, Protein Binding, Female, Gene Expression Regulation, Developmental, Body Patterning, Embryo, Nonmammalian, Oocytes, Alternative Splicing, Drosophila Proteins, Heterogeneous-Nuclear Ribonucleoproteins, Oogenesis, Guanine Nucleotide Exchange Factors, Heterogeneous-Nuclear Ribonucleoprotein Group F-H, Transforming Growth Factor alpha, Untranslated Regions},
  author = {Yossi Kalifa and Stephen Armenti and Elizabeth Gavis},
  title = {Glorund interactions in the regulation of gurken and oskar mRNAs.},
  abstract = {<p>Precise temporal and spatial regulation of gene expression during Drosophila oogenesis is essential for patterning the anterior-posterior and dorsal-ventral body axes. Establishment of the anterior-posterior axis requires posterior localization and translational control of both oskar and nanos mRNAs. Establishment of the dorsal-ventral axis depends on the precise restriction of gurken mRNA and protein to the dorsal-anterior corner of the oocyte. We have previously shown that Glorund, the Drosophila hnRNP F/H homolog, contributes to anterior-posterior axis patterning by regulating translation of nanos mRNA, through a direct interaction with its 3{\textquoteright} untranslated region. To investigate the pleiotropy of the glorund mutant phenotype, which includes dorsal-ventral and nuclear morphology defects, we searched for proteins that interact with Glorund. Here we show that Glorund is part of a complex containing the hnRNP protein Hrp48 and the splicing factor Half-pint and plays a role both in mRNA localization and nurse cell chromosome organization, probably by regulating alternative splicing of ovarian tumor. We propose that Glorund is a component of multiple protein complexes and functions both as a translational repressor and splicing regulator for anterior-posterior and dorsal-ventral patterning.</p>
},
  year = {2009},
  journal = {Dev Biol},
  volume = {326},
  pages = {68-74},
  month = {02/2009},
  issn = {1095-564X},
  doi = {10.1016/j.ydbio.2008.10.032},
  language = {eng},
}