@article{84021,
  keywords = {Animals, signal transduction, Biological Transport, RNA, Messenger, Protein Binding, Female, Gene Expression Regulation, Developmental, Animals, Genetically Modified, Protein-Serine-Threonine Kinases, Drosophila melanogaster, Drosophila Proteins, RNA-Binding Proteins, Checkpoint Kinase 2, Peptide Initiation Factors},
  author = {Agata Becalska and YoungJung Kim and Nicolette Belletier and Dorothy Lerit and Kristina Sinsimer and Elizabeth Gavis},
  title = {Aubergine is a component of a nanos mRNA localization complex.},
  abstract = {<p>Localization of nanos (nos) mRNA to the posterior pole of the Drosophila oocyte is essential for abdominal segmentation and germline development during embryogenesis. Posterior localization is mediated by a complex cis-acting localization signal in the nos 3{\textquoteright} untranslated region that comprises multiple partially redundant elements. Genetic analysis suggests that this signal is recognized by RNA-binding proteins and associated factors that package nos mRNA into a localization competent ribonucleoprotein complex. However, functional redundancy among localization elements has made the identification of individual localization factors difficult. Indeed, only a single direct-acting nos localization factor, Rumpelstiltskin (Rump), has been identified thus far. Through a sensitized genetic screen, we have now identified the Argonaute family member Aubergine (Aub) as a nos localization factor. Aub interacts with nos mRNA in vivo and co-purifies with Rump in an RNA-dependent manner. Our results support a role for Aub, independent of its function in RNA silencing, as a component of a nos mRNA localization complex.</p>
},
  year = {2011},
  journal = {Dev Biol},
  volume = {349},
  pages = {46-52},
  month = {01/2011},
  issn = {1095-564X},
  doi = {10.1016/j.ydbio.2010.10.002},
  language = {eng},
}