@article{bibcite_203441,
  author = {Bezia Lemma and Megan Rothstein and Pengfei Zhang and Bridget Waas and Marcus Kilwein and Safiya Topiwala and Sherry Zhang and Anvitha Sudhakar and Katharine Goodwin and Elizabeth Gavis and Ricardo Mallarino and Andrej Kosmrlj and Celeste Nelson},
  title = {Patterns of mitochondrial ATP predict tissue folding.},
  abstract = {<p>The construction of tissue shapes during embryonic development results from patterns of gene expression and mechanical forces fueled by chemical energy from ATP hydrolysis. We find that chemical energy is similarly patterned during apical constriction, which is widely used across the animal kingdom to fold epithelial tissues. Time-lapse imaging, spatial transcriptomics, and measurements of oxygen consumption rate reveal that mitochondrial density, potential, and ATP increase at the apical side of epithelial cells before actomyosin contraction and tissue folding, which is prevented by inhibiting oxidative phosphorylation. Mitochondrial enrichment and apical bias are conserved during apical constriction in flies, chicks, and mice, and these patterns can be used to predict computationally patterns of tissue folding. These findings highlight a spatial dimension of bioenergetics in development.</p>},
  year = {2026},
  journal = {Science advances},
  volume = {12},
  pages = {eaee6175},
  month = {04/2026},
  issn = {2375-2548},
  doi = {10.1126/sciadv.aee6175},
  language = {eng},
}