@article{203376,
  author = {Bing Ye and Claudia Petritsch and Ira Clark and Elizabeth Gavis and Lily Jan and Yuh Jan},
  title = {Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.},
  abstract = {<p>Much attention has focused on dendritic translational regulation of neuronal signaling and plasticity. For example, long-term memory in adult Drosophila requires Pumilio (Pum), an RNA binding protein that interacts with the RNA binding protein Nanos (Nos) to form a localized translation repression complex essential for anterior-posterior body patterning in early embryogenesis. Whether dendrite morphogenesis requires similar translational regulation is unknown. Here we report that nos and pum control the elaboration of high-order dendritic branches of class III and IV, but not class I and II, dendritic arborization (da) neurons. Analogous to their function in body patterning, nos and pum require each other to control dendrite morphogenesis, a process likely to involve translational regulation of nos itself. The control of dendrite morphogenesis by Nos/Pum, however, does not require hunchback, which is essential for body patterning. Interestingly, Nos protein is localized to RNA granules in the dendrites of da neurons, raising the possibility that the Nos/Pum translation repression complex operates in dendrites. This work serves as an entry point for future studies of dendritic translational control of dendrite morphogenesis.</p>
},
  year = {2004},
  journal = {Current biology : CB},
  volume = {14},
  pages = {314-21},
  month = {02/2004},
  issn = {0960-9822},
  language = {eng},
}